Monoclonal Antibodies for the Treatment of Nasal Polyps

Thomas J Willson; Robert M Naclerio; Stella E Lee

doi:10.1016/j.iac.2017.01.008

Monoclonal Antibodies for the Treatment of Nasal Polyps

Immunol Allergy Clin North Am. 2017 May;37(2):357-367. doi: 10.1016/j.iac.2017.01.008. Epub 2017 Mar 2.

Authors

Thomas J Willson¹, Robert M Naclerio², Stella E Lee³

Affiliations

¹ Department of Otolaryngology, Head & Neck Surgery, University of Pittsburgh Medical Center, 1400 Locust Street, Suite 2100, Building D, Pittsburgh, PA 15219, USA.
² Section of Otolaryngology, Head & Neck Surgery, The University of Chicago Medical Center, MC 1035, 5841 South Maryland Avenue, Chicago, IL 60615, USA.
³ Department of Otolaryngology, Head & Neck Surgery, University of Pittsburgh Medical Center, 1400 Locust Street, Suite 2100, Building D, Pittsburgh, PA 15219, USA. Electronic address: lees6@upmc.edu.

PMID: 28366482
DOI: 10.1016/j.iac.2017.01.008

Abstract

Biologics are novel therapeutic medications developed for the targeted therapy for a variety of inflammatory conditions. The biologics currently investigated for the treatment of chronic rhinosinusitis (CRS) with nasal polyps modulate specific inflammatory pathways involved in the pathogenesis of disease. Investigations have focused on the most severe form of the disease, namely, CRS with nasal polyps. It is hoped that specific targeted therapies using these biologics can significantly modulate the immune system, offering both disease control and symptomatic relief. This review summarizes those therapies that have been used to treat nasal polyps.

Keywords: Allergic rhinitis; Asthma; Biologics; Chronic rhinosinusitis; Nasal polyps.

Publication types

Review

MeSH terms

Antibodies, Anti-Idiotypic / pharmacology
Antibodies, Anti-Idiotypic / therapeutic use
Antibodies, Monoclonal / pharmacology
Antibodies, Monoclonal / therapeutic use*
Biomarkers
Chronic Disease
Humans
Immunomodulation / drug effects
Interleukin-13 / metabolism
Interleukin-4 / metabolism
Interleukin-5 / antagonists & inhibitors
Interleukin-5 / metabolism
Molecular Targeted Therapy
Nasal Polyps / drug therapy*
Nasal Polyps / etiology
Nasal Polyps / metabolism
Rhinitis / complications
Rhinitis / drug therapy
Rhinitis / immunology
Rhinitis / metabolism
Sialic Acid Binding Immunoglobulin-like Lectins / pharmacology
Sialic Acid Binding Immunoglobulin-like Lectins / therapeutic use
Signal Transduction / drug effects
Sinusitis / complications
Sinusitis / drug therapy
Sinusitis / immunology
Sinusitis / metabolism

Substances

Antibodies, Anti-Idiotypic
Antibodies, Monoclonal
Biomarkers
Interleukin-13
Interleukin-5
Sialic Acid Binding Immunoglobulin-like Lectins
anti-IgE antibodies
Interleukin-4