Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease

Circ Res. 2017 Mar 31;120(7):1174-1182. doi: 10.1161/CIRCRESAHA.117.303776.

Abstract

Endothelial cells lining the vessel wall control important aspects of vascular homeostasis. In particular, the production of endothelium-derived nitric oxide and activation of soluble guanylate cyclase promotes endothelial quiescence and governs vasomotor function and proportional remodeling of blood vessels. Here, we discuss novel approaches to improve endothelial nitric oxide generation and preserve its bioavailability. We also discuss therapeutic opportunities aimed at activation of soluble guanylate cyclase for multiple cardiovascular indications.

Keywords: caveolin-1; endothelial cells; heart failure; nitrates; nitric oxide.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / metabolism*
  • Cyclic GMP / metabolism*
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Guanylate Cyclase / antagonists & inhibitors*
  • Humans
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase Type III / antagonists & inhibitors
  • Phosphodiesterase Inhibitors / pharmacology

Substances

  • Phosphodiesterase Inhibitors
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Guanylate Cyclase
  • Cyclic GMP