Pushing Yap into the Nucleus with Shear Force

Jason Kuan Han Lai; Didier Y R Stainier

doi:10.1016/j.devcel.2017.03.008

Pushing Yap into the Nucleus with Shear Force

Dev Cell. 2017 Mar 27;40(6):517-518. doi: 10.1016/j.devcel.2017.03.008.

Authors

Jason Kuan Han Lai¹, Didier Y R Stainier²

Affiliations

¹ Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Electronic address: jason.lai@mpi-bn.mpg.de.
² Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany. Electronic address: didier.stainier@mpi-bn.mpg.de.

PMID: 28350983
DOI: 10.1016/j.devcel.2017.03.008

Abstract

Endothelial cells line blood vessels and experience shear stress from blood flow. In this issue of Developmental Cell, Nakajima and colleagues (2017) show that in zebrafish Yap responds to blood flow by translocating into the nucleus, where it drives a genetic program to maintain vascular stability.

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MeSH terms

Animals
Cell Nucleus
Endothelial Cells*
Endothelium
Stress, Mechanical*
Zebrafish