A new α-pyrone from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111(T)

J Asian Nat Prod Res. 2017 Dec;19(12):1232-1238. doi: 10.1080/10286020.2017.1307186. Epub 2017 Mar 28.

Abstract

A new α-pyrone, nocapyrone S (1), together with five known compounds (2-6), were isolated from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111(T). Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by quantum approaches. Cytotoxic activity of 1 was evaluated against K562, MCF-7, SGC7901, A375, Hela, and HepG2 cell lines.

Keywords: Nocardiopsis dassonvillei; deep-sea actinomycete; α-pyrone.

MeSH terms

  • Actinomycetales / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • K562 Cells
  • MCF-7 Cells
  • Marine Biology
  • Molecular Structure
  • Nocardia / chemistry*
  • Pyrones / chemistry
  • Pyrones / isolation & purification*
  • Pyrones / pharmacology

Substances

  • Antineoplastic Agents
  • Pyrones
  • nocapyrone S