Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1

A Cosson; E Chapiro; N Bougacha; J Lambert; L Herbi; H-A Cung; C Algrin; B Keren; F Damm; C Gabillaud; M-N Brunelle-Navas; F Davi; H Merle-Béral; M Le Garff-Tavernier; D Roos-Weil; S Choquet; M Uzunov; V Morel; V Leblond; K Maloum; S Lepretre; P Feugier; C Lesty; J Lejeune; L Sutton; Y Landesman; S A Susin; F Nguyen-Khac

doi:10.1038/leu.2017.100

Gain in the short arm of chromosome 2 (2p+) induces gene overexpression and drug resistance in chronic lymphocytic leukemia: analysis of the central role of XPO1

Leukemia. 2017 Jul;31(7):1625-1629. doi: 10.1038/leu.2017.100. Epub 2017 Mar 27.

Authors

A Cosson^{1

2

3}, E Chapiro^{1

2

4}, N Bougacha^{1

2

3}, J Lambert⁵, L Herbi^{1

2

3}, H-A Cung⁴, C Algrin⁴, B Keren⁶, F Damm⁷, C Gabillaud⁴, M-N Brunelle-Navas^{1

2

3}, F Davi^{1

2

4}, H Merle-Béral^{1

2

4}, M Le Garff-Tavernier^{1

2

4}, D Roos-Weil⁷, S Choquet⁴, M Uzunov⁴, V Morel⁴, V Leblond⁴, K Maloum⁴, S Lepretre⁸, P Feugier⁹, C Lesty⁴, J Lejeune⁵, L Sutton¹⁰, Y Landesman¹¹, S A Susin^{1

2

3}, F Nguyen-Khac^{1

2

4}

Affiliations

¹ INSERM UMR_S 1138, Cell Death and Drug Resistance in Lymphoproliferative Disorders Team, Centre de Recherche des Cordeliers, Paris, France.
² Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
³ Université Paris Descartes, Sorbonne Paris Cité, UMR_S 1138, Centre de Recherche des Cordeliers, Paris, France.
⁴ Service d'Hématologie Biologique, GH Pitié-Salpêtrière, Paris, France.
⁵ Service de Biostatistique et Informatique Médicale, Hôpital Saint Louis, Paris, France.
⁶ Département de génétique, GH Pitié-Salpêtrière, Paris, France.
⁷ INSERM U1170, Institut Gustave Roussy, Villejuif, France.
⁸ Département d'Hématologie, Hôpital Becquerel, Rouen, France.
⁹ Pôle d'Hématologie, Hôpital Brabois, Vandoeuvre-les-Nancy, France.
¹⁰ Service d'Hématologie Clinique, Hôpital d'Argenteuil, Argenteuil, France.
¹¹ Karyopharm Therapeutics, Newton, MA, USA.

PMID: 28344316
DOI: 10.1038/leu.2017.100

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Chromosomes, Human, Pair 2*
Drug Resistance, Neoplasm / drug effects
Drug Resistance, Neoplasm / genetics*
Exportin 1 Protein
Gene Expression Regulation, Leukemic*
Humans
Hydrazines / pharmacology
Hydrazines / therapeutic use*
Karyopherins / genetics*
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy*
Leukemia, Lymphocytic, Chronic, B-Cell / genetics
Receptors, Cytoplasmic and Nuclear / genetics*
Triazoles / pharmacology
Triazoles / therapeutic use*

Substances

Hydrazines
Karyopherins
Receptors, Cytoplasmic and Nuclear
Triazoles
selinexor