Keeping fat on time: Circadian control of adipose tissue

Stine Ninel Hansen; Julia Peics; Zachary Gerhart-Hines

doi:10.1016/j.yexcr.2017.03.045

Keeping fat on time: Circadian control of adipose tissue

Exp Cell Res. 2017 Nov 1;360(1):31-34. doi: 10.1016/j.yexcr.2017.03.045. Epub 2017 Mar 23.

Authors

Stine Ninel Hansen¹, Julia Peics¹, Zachary Gerhart-Hines¹

Affiliation

¹ Section for Metabolic Receptology at the Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen 2200, Denmark.

PMID: 28344052
DOI: 10.1016/j.yexcr.2017.03.045

Abstract

Circadian clocks harmonize processes ranging from intracellular biochemistry to whole-body physiology in accordance with the Earth's 24h rotation. These intrinsic oscillators are based on an interlocked transcriptional-translational feedback loop comprised from a set of core clock factors. In addition to maintaining rhythmicity in nearly every cell of the body, these clock factors also mediate tissue specific metabolic functions. In this review, we will explore how the molecular clock shapes the unique features of different adipose depots.

Keywords: Adipose tissue; Brown, Beige, and white fat; Circadian rhythm; Molecular clock.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue / physiology*
Animals
Circadian Rhythm / physiology*
Humans