Management of adult infectious encephalitis in metropolitan France

T Goulenok; R Buzelé; X Duval; F Bruneel; J P Stahl; B Fantin

doi:10.1016/j.medmal.2017.01.006

Management of adult infectious encephalitis in metropolitan France

Med Mal Infect. 2017 May;47(3):206-220. doi: 10.1016/j.medmal.2017.01.006. Epub 2017 Mar 20.

Authors

T Goulenok¹, R Buzelé², X Duval³, F Bruneel⁴, J P Stahl⁵, B Fantin⁶

Affiliations

¹ Service de médecine interne, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France. Electronic address: tiphaine.goulenok@aphp.fr.
² Service de médecine interne, centre hospitalier de Saint-Brieuc, 10, rue Marcel-Proust, 22000 Saint-Brieuc, France. Electronic address: rodolphe.buzele@outlook.fr.
³ Centre d'investigation clinique 1425, hôpital Bichat-Claude-Bernard, AP-HP, 46, rue Henri-Huchard, 75018 Paris, France. Electronic address: xavier.duval@aphp.fr.
⁴ Service de réanimation médico-chirurgicale, centre hospitalier de Versailles, hôpital André-Mignot, 177, rue de Versailles, 78150 Le Chesnay, France. Electronic address: fbruneel@ch-versailles.fr.
⁵ Infectiologie, "European study Group for the Infections of the Brain (ESGIB)", CHU Grenoble, 38000 Grenoble, France. Electronic address: JPStahl@chu-grenoble.fr.
⁶ Service de médecine interne, hôpital Beaujon, AP-HP, 100, boulevard du Général-Leclerc, 92110 Clichy, France; Inserm, IAME, UMR 1137, 75018 Paris, France; Université Paris Diderot, Sorbonne Paris Cité, 75018 Paris, France. Electronic address: bruno.fantin@aphp.fr.

PMID: 28336304
DOI: 10.1016/j.medmal.2017.01.006

Abstract

Infectious encephalitis is a severe disease leading to a high mortality and morbidity. The most frequent causes include Herpes simplex virus, Varicella Zoster virus, Listeria monocytogenes, and Mycobacterium tuberculosis. Urgent treatment is required (anti-infective therapy and nonspecific supportive care). The aim of this study was to define treatment strategy, empirical and after microbiological documentation at 48hours, through a systematic literature review.

Keywords: Encéphalite infectieuse; HSV; Infectious encephalitis; Listeria; Tuberculose; Tuberculosis; VZV.

Publication types

Review
Systematic Review

MeSH terms

Adult
Anti-Infective Agents / therapeutic use
Anticonvulsants / therapeutic use
Brain Damage, Chronic / prevention & control
Critical Care
Diagnosis, Differential
Disease Management
France / epidemiology
Hospitalization
Humans
Hypertonic Solutions / therapeutic use
Hypothermia, Induced
Infectious Encephalitis / complications
Infectious Encephalitis / epidemiology
Infectious Encephalitis / therapy*

Substances

Anti-Infective Agents
Anticonvulsants
Hypertonic Solutions