Lymphocyte-rich capillary-cavernous hemangioma of the mitral valve: a case report and review of the literature

Cardiovasc Pathol. 2017 May-Jun:28:59-63. doi: 10.1016/j.carpath.2017.03.003. Epub 2017 Mar 10.

Abstract

Valvular hemangioma incidence is extremely low. In this report, we describe a 62-year-old man who presented with mild edema of the lower limbs. An echocardiogram revealed an incidental 1.3-cm diameter mass on the anterior mitral valve leaflet for which he underwent surgical resection and mitral valve replacement. Histopathological examination showed a lymphocyte-rich capillary-cavernous hemangioma. The exuberant lymphoid stroma is unusual for hemangioma and represents an undescribed pattern of cardiac hemangioma. Including the present report, only 13 cases of mitral valve hemangioma have been reported to date. Most patients are adult. Mitral hemangioma originates in the atrial aspect of the valve and involves more commonly the anterior leaflet. The average maximum diameter of the lesion is 1.7 (S.D.=0.75) cm. Pure cavernous hemangioma is the predominant type of mitral hemangioma. Most of them are described as pedunculated or polypoid. Surgical excision appears to be curative. Recurrences have not been reported. Lymphocyte-rich cardiac hemangioma represents a peculiar type of hemangioma which should be included in the differential diagnosis of other vascular lesions.

Keywords: Benign tumor; Hemangioma; Lymphocyte rich; Mitral valve.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biopsy
  • Echocardiography
  • Heart Neoplasms / chemistry
  • Heart Neoplasms / immunology
  • Heart Neoplasms / pathology*
  • Heart Neoplasms / surgery
  • Heart Valve Prosthesis Implantation
  • Hemangioma, Capillary / chemistry
  • Hemangioma, Capillary / immunology
  • Hemangioma, Capillary / pathology*
  • Hemangioma, Capillary / surgery
  • Hemangioma, Cavernous / chemistry
  • Hemangioma, Cavernous / immunology
  • Hemangioma, Cavernous / pathology*
  • Hemangioma, Cavernous / surgery
  • Humans
  • Immunohistochemistry
  • Incidental Findings
  • Lymphocytes, Tumor-Infiltrating / chemistry
  • Lymphocytes, Tumor-Infiltrating / immunology
  • Lymphocytes, Tumor-Infiltrating / pathology*
  • Male
  • Middle Aged
  • Mitral Valve / chemistry
  • Mitral Valve / immunology
  • Mitral Valve / pathology*
  • Mitral Valve / surgery
  • Treatment Outcome

Substances

  • Biomarkers, Tumor