Interleukin-17: Why the Worms Squirm

Noah J Silverstein; Jun R Huh

doi:10.1016/j.immuni.2017.03.007

Interleukin-17: Why the Worms Squirm

Immunity. 2017 Mar 21;46(3):347-349. doi: 10.1016/j.immuni.2017.03.007.

Authors

Noah J Silverstein¹, Jun R Huh²

Affiliations

¹ Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Division of Infectious Diseases and Immunology and Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: jun.huh@umassmed.edu.

PMID: 28329701
DOI: 10.1016/j.immuni.2017.03.007

Abstract

IL-17 is a cytokine known primarily for its role in inflammation. In a recent issue of Nature, Chen et al. (2017) demonstrate that IL-17 plays a neuromodulatory role in Caenorhabditis elegans by acting directly on neurons to amplify neuronal responses to stimuli and produce changes in animal behavior.

Publication types

Comment

MeSH terms

Animals
Behavior, Animal
Caenorhabditis elegans*
Interleukin-17*
Neurons

Substances

Interleukin-17