Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics

Longguang Tang; Fuwu Zhang; Fei Yu; Wenjing Sun; Menglin Song; Xiaoyuan Chen; Xianzhong Zhang; Xiaolian Sun

doi:10.1016/j.biomaterials.2017.03.009

Croconaine nanoparticles with enhanced tumor accumulation for multimodality cancer theranostics

Biomaterials. 2017 Jun:129:28-36. doi: 10.1016/j.biomaterials.2017.03.009. Epub 2017 Mar 13.

Authors

Longguang Tang¹, Fuwu Zhang², Fei Yu¹, Wenjing Sun¹, Menglin Song¹, Xiaoyuan Chen², Xianzhong Zhang³, Xiaolian Sun⁴

Affiliations

¹ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China.
² Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, United States.
³ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China. Electronic address: zhangxzh@xmu.edu.cn.
⁴ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361005, China. Electronic address: xiaolian-sun@xmu.edu.cn.

PMID: 28324863
DOI: 10.1016/j.biomaterials.2017.03.009

Abstract

A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention). These facilely synthesized molecular nanoprobes showed great clinical translation potential as a versatile theranostic agent.

Keywords: Controlled assembly; EPR effect; Molecular nanoprobe; Multimodality imaging; Photothermal therapy.

MeSH terms

Animals
Cell Death
Coloring Agents / chemistry
Combined Modality Therapy
Endocytosis
Female
Humans
MCF-7 Cells
Mice, Nude
Microscopy, Fluorescence
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Neoplasms / pathology
Neoplasms / therapy*
Photoacoustic Techniques
Polyethylene Glycols / chemistry*
Subcellular Fractions / metabolism
Temperature
Theranostic Nanomedicine*
Thiophenes / chemistry*

Substances

CR780-PEG5K
Coloring Agents
Thiophenes
Polyethylene Glycols