Caffeine, creatine, GRIN2A and Parkinson's disease progression

J Neurol Sci. 2017 Apr 15:375:355-359. doi: 10.1016/j.jns.2017.02.032. Epub 2017 Feb 17.

Abstract

Caffeine is neuroprotective in animal models of Parkinson's disease (PD) and caffeine intake is inversely associated with the risk of PD. This association may be influenced by the genotype of GRIN2A, which encodes an NMDA-glutamate-receptor subunit. In two placebo-controlled studies, we detected no association of caffeine intake with the rate of clinical progression of PD, except among subjects taking creatine, for whom higher caffeine intake was associated with more rapid progression. We now have analyzed data from 420 subjects for whom DNA samples and caffeine intake data were available from a placebo-controlled study of creatine in PD. The GRIN2A genotype was not associated with the rate of clinical progression of PD in the placebo group. However, there was a 4-way interaction between GRIN2A genotype, caffeine, creatine and the time since baseline. Among subjects in the creatine group with high levels of caffeine intake, but not among those with low caffeine intake, the GRIN2A T allele was associated with more rapid progression (p=0.03). These data indicate that the deleterious interaction between caffeine and creatine with respect to rate of progression of PD is influenced by GRIN2A genotype. This example of a genetic factor interacting with environmental factors illustrates the complexity of gene-environment interactions in the progression of PD.

Keywords: Caffeine; Coffee; Creatine; GRIN2A; Parkinson's disease; Progression.

MeSH terms

  • Aged
  • Caffeine / metabolism
  • Caffeine / therapeutic use*
  • Creatine / therapeutic use*
  • Disease Progression
  • Female
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Parkinson Disease / drug therapy*
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, N-Methyl-D-Aspartate / genetics*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • Caffeine
  • Creatine
  • N-methyl D-aspartate receptor subtype 2A