Decentralized safety concept for closed-loop controlled intensive care

Biomed Tech (Berl). 2017 Apr 1;62(2):213-223. doi: 10.1515/bmt-2016-0087.

Abstract

This paper presents a decentralized safety concept for networked intensive care setups, for which a decentralized network of sensors and actuators is realized by embedded microcontroller nodes. It is evaluated for up to eleven medical devices in a setup for automated acute respiratory distress syndrome (ARDS) therapy. In this contribution we highlight a blood pump supervision as exemplary safety measure, which allows a reliable bubble detection in an extracorporeal blood circulation. The approach is validated with data of animal experiments including 35 bubbles with a size between 0.05 and 0.3 ml. All 18 bubbles with a size down to 0.15 ml are successfully detected. By using hidden Markov models (HMMs) as statistical method the number of necessary sensors can be reduced by two pressure sensors.

Keywords: ARDS; ECMO; blood pump; bubble detection; decentralized supervision; distributed systems; fault detection; hidden Markov models.

MeSH terms

  • Animals
  • Clinical Alarms*
  • Critical Care / methods*
  • Extracorporeal Circulation / methods*
  • Feedback, Physiological
  • Humans
  • Monitoring, Physiologic / instrumentation
  • Monitoring, Physiologic / methods*
  • Patient Safety
  • Pattern Recognition, Automated / methods
  • Respiratory Distress Syndrome / diagnosis*
  • Respiratory Distress Syndrome / therapy*
  • Therapy, Computer-Assisted / methods*
  • Treatment Outcome