Abstract
A new series of pyrrolopyridines and pyrrolopyridopyrimidines have been synthesized from aminocyanopyrroles. The synthesized compounds have been characterized by FTIR, ¹H-NMR and mass spectroscopy. The final compounds have been screened for in vitro pro-inflammatory cytokine inhibitory and in vivo anti-inflammatory activity. The biological results revealed that among all tested compounds some fused pyrroles, namely the pyrrolopyridines 3i and 3l, show promising activity. A docking study of the active synthesized molecules confirmed the biological results and revealed a new binding pose in the COX-2 binding site.
Keywords:
anti-inflammatory assay; cytokine inhibitors; docking study; pyrroles; pyrrolopyridines; synthesis.
MeSH terms
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Animals
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Anti-Inflammatory Agents / chemical synthesis
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Anti-Inflammatory Agents / chemistry*
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Anti-Inflammatory Agents / pharmacology*
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Cytokines / antagonists & inhibitors
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Cytokines / chemistry
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Inflammation Mediators / antagonists & inhibitors*
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Inflammation Mediators / chemistry
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Male
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Molecular Conformation
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Molecular Docking Simulation
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Molecular Dynamics Simulation
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Molecular Structure
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Pyrimidines
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Pyrroles / chemical synthesis
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Pyrroles / chemistry*
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Pyrroles / pharmacology*
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Rats
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Structure-Activity Relationship
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Cytokines
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Inflammation Mediators
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Pyrimidines
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Pyrroles