Room-temperature synthesis of core-shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

Guo Lin; Chaohong Gao; Qiong Zheng; Zhixian Lei; Huijuan Geng; Zian Lin; Huanghao Yang; Zongwei Cai

doi:10.1039/c7cc00482f

Room-temperature synthesis of core-shell structured magnetic covalent organic frameworks for efficient enrichment of peptides and simultaneous exclusion of proteins

Chem Commun (Camb). 2017 Mar 28;53(26):3649-3652. doi: 10.1039/c7cc00482f.

Authors

Guo Lin¹, Chaohong Gao¹, Qiong Zheng¹, Zhixian Lei¹, Huijuan Geng¹, Zian Lin¹, Huanghao Yang¹, Zongwei Cai²

Affiliations

¹ Ministry of Education Key Laboratory of Analysis and Detection for Food Safety, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China. zianlin@fzu.edu.cn.
² Partner State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong SAR, P. R. China. zwcai@hkbu.edu.hk.

PMID: 28304044
DOI: 10.1039/c7cc00482f

Abstract

Core-shell structured magnetic covalent organic frameworks (Fe₃O₄@COFs) were synthesized via a facile approach at room temperature. Combining the advantages of high porosity, magnetic responsiveness, chemical stability and selectivity, Fe₃O₄@COFs can serve as an ideal absorbent for the highly efficient enrichment of peptides and the simultaneous exclusion of proteins from complex biological samples.