Covalent Modifications of RUNX Proteins: Structure Affects Function

Adv Exp Med Biol. 2017:962:33-44. doi: 10.1007/978-981-10-3233-2_3.

Abstract

The RUNX family of transcription factors plays important roles in tissue-specific gene expression. Many of their functions depend on specific post-translational modifications (PTMs), and in this review, we describe how PTMs govern RUNX DNA binding, transcriptional activity, protein stability, cellular localization, and protein-protein interactions. We also report how these processes can be disrupted in disease settings. Finally, we describe how alterations of RUNX1, or the enzymes that catalyze its post-translational modifications, contribute to hematopoietic malignancies.

Keywords: Acetylation; Acute Myeloid Leukemia; CBFβ; Cleidocranial Dysplasia; FPD/AML; Methylation; Phosphorylation; Post-Translational Modifications; RUNX1; RUNX2; RUNX3; Transcriptional Activation; Transcriptional Repression; Ubiquitylation.

Publication types

  • Review

MeSH terms

  • Animals
  • Core Binding Factor alpha Subunits / genetics*
  • Core Binding Factor alpha Subunits / metabolism*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism
  • Humans
  • Protein Interaction Maps / genetics
  • Protein Processing, Post-Translational / genetics
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcription, Genetic / genetics

Substances

  • Core Binding Factor alpha Subunits
  • DNA-Binding Proteins
  • Transcription Factors