Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis

Peipei Guo; Shahin Rafii

doi:10.1016/j.ccell.2017.02.016

Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis

Cancer Cell. 2017 Mar 13;31(3):301-303. doi: 10.1016/j.ccell.2017.02.016.

Authors

Peipei Guo¹, Shahin Rafii²

Affiliations

¹ Department of Medicine, Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10021, USA.
² Department of Medicine, Division of Regenerative Medicine, Ansary Stem Cell Institute, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: srafii@med.cornell.edu.

PMID: 28292430
DOI: 10.1016/j.ccell.2017.02.016

Abstract

In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.

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MeSH terms

Cell Adhesion
Cell Line, Tumor*
Endothelial Cells / metabolism
Endothelium*
Endothelium, Vascular
Humans
Signal Transduction