Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C-O Bond Cleavage

Huifeng Yue; Lin Guo; Xiangqian Liu; Magnus Rueping

doi:10.1021/acs.orglett.7b00556

Nickel-Catalyzed Synthesis of Primary Aryl and Heteroaryl Amines via C-O Bond Cleavage

Org Lett. 2017 Apr 7;19(7):1788-1791. doi: 10.1021/acs.orglett.7b00556. Epub 2017 Mar 13.

Authors

Huifeng Yue¹, Lin Guo¹, Xiangqian Liu¹, Magnus Rueping^{1

2}

Affiliations

¹ Institute of Organic Chemistry, RWTH Aachen University , Landoltweg 1, 52074 Aachen, Germany.
² King Abdullah University of Science and Technology (KAUST)KAUST Catalysis Center (KCC) , Thuwal, 23955-6900 Saudi Arabia.

PMID: 28287744
DOI: 10.1021/acs.orglett.7b00556

Abstract

A nickel-catalyzed protocol for the conversion of aryl and heteroaryl alcohol derivatives to primary and secondary aromatic amines via C(sp²)-O bond cleavage is described. The new amination protocol can be applied to a range of substrates bearing diverse functional groups and uses readily available benzophenone imines as an effective nitrogen source.

Publication types

Research Support, Non-U.S. Gov't