Structure revision of aspergicin by the crystal structure of aspergicine, a co-occurring isomer produced by co-culture of two mangrove epiphytic fungi

Nat Prod Res. 2017 Oct;31(19):2268-2272. doi: 10.1080/14786419.2017.1300800. Epub 2017 Mar 13.

Abstract

The structure of aspergicin (1), an antibacterial alkaloid produced by co-culture of two marine-derived mangrove epiphytic fungi, were revised by the co-occurring isomer named as aspergicine (2), whose structure was determined on the basis of spectroscopic analysis and X-ray crystallography.

Keywords: Aspergillus; Avicennia marina; X-ray crystallography; aspergicin; structure revision.

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology
  • Anti-Bacterial Agents / chemistry*
  • Coculture Techniques
  • Crystallography, X-Ray
  • Fungi / chemistry*
  • Isomerism
  • Molecular Structure
  • Spectrum Analysis

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • aspergicin