Abstract
Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3'-untranslated regions (UTRs) of mRNAs. mRNA 3'-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate. [BMB Reports 2017; 50(4): 194-200].
MeSH terms
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3' Untranslated Regions
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Animals
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Eukaryotic Initiation Factor-4E / chemistry
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Eukaryotic Initiation Factor-4E / genetics
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Eukaryotic Initiation Factor-4E / metabolism
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Eukaryotic Initiation Factor-4G / chemistry
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Eukaryotic Initiation Factor-4G / genetics
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Eukaryotic Initiation Factor-4G / metabolism
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Humans
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Poly A / genetics
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Poly A / metabolism
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Protein Biosynthesis / physiology*
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RNA, Messenger / genetics
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RNA, Messenger / metabolism*
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism*
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Regulatory Elements, Transcriptional
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Ribosomes / metabolism
Substances
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3' Untranslated Regions
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Eukaryotic Initiation Factor-4E
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Eukaryotic Initiation Factor-4G
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RNA, Messenger
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RNA-Binding Proteins
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Poly A