Approximately 50 million people live with epilepsy worldwide. The aim of this review is to present an overview of the current evidence and management recommendations for evaluation and treatment of patients with epilepsy. Systematic literature reviews were undertaken. A review of contemporary published evidence-based guidelines (American Academy of Neurology, American Epilepsy Society, and the Indian Epilepsy Society) and published peer reviewed scientific publications was done. The guideline is addressed to all clinicians who manage epilepsy patients. Evidence-based recommendations are provided for the evaluation and treatment of the first seizure, use of antiepileptic medications, treatment of status epilepticus, use of epilepsy surgery, and the management of epilepsy in specific populations as well as in unique clinical situations such as neurocysticercosis infestation, brain tumor and human immunodeficiency virus infection. It also addresses the special considerations in women with epilepsy.