A case of coexistence of TSH/GH-secreting pituitary tumor and papillary thyroid carcinoma: Challenges in pathogenesis and management

J Clin Neurosci. 2017 Jul:41:78-80. doi: 10.1016/j.jocn.2017.02.050. Epub 2017 Mar 6.

Abstract

Co-existence of thyrotropin/growth hormone-secreting pituitary adenoma with differentiated thyroid carcinoma is exceedingly rare, with less than 15 cases having been reported. Its clinical presentation and treatment strategy are challenging. We report a case of pituitary macroadenoma, with clinical syndromes of acromegaly and hyperthyroidism, and a thyroid nodule, with cytologically confirmed to be a papillary thyroid carcinoma. Clinical implications, focusing on the strategy for proper management, and possible pathogenesis were discussed.

Keywords: Acromegaly; Inappropriate TSH secretion; Pituitary tumor; TSHoma; Thyroid carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Papillary / complications*
  • Carcinoma, Papillary / diagnosis
  • Carcinoma, Papillary / etiology
  • Female
  • Growth Hormone-Secreting Pituitary Adenoma / complications*
  • Growth Hormone-Secreting Pituitary Adenoma / diagnosis
  • Growth Hormone-Secreting Pituitary Adenoma / etiology
  • Humans
  • Hyperthyroidism / complications*
  • Hyperthyroidism / diagnosis
  • Hyperthyroidism / etiology
  • Middle Aged
  • Pituitary Neoplasms / complications*
  • Pituitary Neoplasms / diagnosis
  • Pituitary Neoplasms / etiology
  • Thyroid Cancer, Papillary
  • Thyroid Neoplasms / complications*
  • Thyroid Neoplasms / diagnosis
  • Thyroid Neoplasms / etiology
  • Thyrotropin / blood

Substances

  • Thyrotropin