Imaging of Prostate Cancer Using 64Cu-Labeled Prostate-Specific Membrane Antigen Ligand

PET Clin. 2017 Apr;12(2):193-203. doi: 10.1016/j.cpet.2016.12.001. Epub 2017 Jan 31.

Abstract

Prostate cancer is the most common noncutaneous cancer among men, rendering the diagnosis and staging of significant medical and public interest. One of the most interesting developments in the application of nuclear oncology has been the development of novel diagnostic agents that are able to facilitate targeted therapies using the concept of theranostics. This review summarizes the current and emerging molecular imaging techniques for the investigation of patients with prostate cancer with emphasis on the potential of 64Cu-PSMA PET/CT in staging, restaging, and the application of theranostics.

Keywords: (64)Cu-PSMA; Molecular imaging; Prostate cancer.

Publication types

  • Review

MeSH terms

  • Antigens, Surface*
  • Copper Radioisotopes*
  • Glutamate Carboxypeptidase II*
  • Humans
  • Male
  • Multimodal Imaging / methods
  • Neoplasm Staging
  • Positron Emission Tomography Computed Tomography / methods
  • Positron-Emission Tomography / methods
  • Prostatic Neoplasms / diagnostic imaging*
  • Radiopharmaceuticals*

Substances

  • Antigens, Surface
  • Copper Radioisotopes
  • Radiopharmaceuticals
  • FOLH1 protein, human
  • Glutamate Carboxypeptidase II