Efficient generation of mice carrying homozygous double-floxp alleles using the Cas9-Avidin/Biotin-donor DNA system

Cell Res. 2017 Apr;27(4):578-581. doi: 10.1038/cr.2017.29. Epub 2017 Mar 7.

Ming Ma¹, Fengfeng Zhuang², Xiongbing Hu², Bolun Wang¹, Xian-Zi Wen³, Jia-Fu Ji³, Jianzhong Jeff Xi^{1

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¹ Department of Biomedical Engineering, State Key Laboratory of Natural and Biomimetic Drugs, College of Engineering, Peking University, Beijing, China.
² Beijing Viewsolid Biotech Co. Ltd, Beijing 100071, China.
³ Division of Gastrointestinal Cancer Translational Research Laboratory, Department of Gastrointestinal Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Fu-Cheng Road, Beijing, China.
⁴ State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Molecular Medicine, Peking University, Beijing 100871, China.
⁵ Collaborative Innovation Center for Cardiovascular Disorders, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.

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