Low cost, highly efficient and safe devices for energy storage have long been desired in our society. Among these devices, electrochemical batteries with alkali metal anodes have attracted worldwide attention. However, the practical application of such systems is limited by dendrite formation and low cycling efficiency of alkali metals. Here we report a class of liquid anodes fabricated by dissolving sodium metal into a mixed solution of biphenyl and ethers. Such liquid anodes are highly safe and have a low redox potential of 0.09 V versus sodium, exhibiting a high conductivity of 1.2 × 10-2 S cm-1. When coupled with polysulfides dissolved in dimethyl sulfoxide as the cathode, a battery is demonstrated to sustain over 3,500 cycles without measureable capacity loss at room temperature. This work provides a base for exploring a family of liquid anodes for rechargeable batteries that potentially meet the requirements for grid-scale electrical energy storage.