Aquaporins in Cardiovascular System

Adv Exp Med Biol. 2017:969:105-113. doi: 10.1007/978-94-024-1057-0_6.

Abstract

Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure , hypertension and angiogenesis. Therefore, it is important to understand the accurate association between AQPs and cardiovascular system, which may provide novel approaches to prevent and treat related diseases. Here we will discuss the expression and physiological function of AQPs in cardiovascular system and summarize recent researches on AQPs related cardiovascular diseases.

Keywords: Angiogenesis; Aquaporin; Cerebral ischemia; Congestion heart failure; Hypertension.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Aquaporin 1 / genetics
  • Aquaporin 1 / metabolism*
  • Biological Transport
  • Brain Ischemia / genetics
  • Brain Ischemia / metabolism*
  • Brain Ischemia / pathology
  • Cardiovascular System / cytology
  • Cardiovascular System / metabolism*
  • Endothelial Cells / cytology
  • Endothelial Cells / metabolism
  • Gene Expression Regulation
  • Heart Failure / genetics
  • Heart Failure / metabolism*
  • Heart Failure / pathology
  • Humans
  • Hypertension / genetics
  • Hypertension / metabolism*
  • Hypertension / pathology
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism*
  • Neovascularization, Pathologic / pathology
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Water / metabolism

Substances

  • AQP1 protein, human
  • Protein Isoforms
  • Water
  • Aquaporin 1