Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream

Yumiao Zhang; Hao Hong; Boyang Sun; Kevin Carter; Yiru Qin; Wei Wei; Depeng Wang; Mansik Jeon; Jumin Geng; Robert J Nickles; Guanying Chen; Paras N Prasad; Chulhong Kim; Jun Xia; Weibo Cai; Jonathan F Lovell

doi:10.1039/c6nr09321c

Surfactant-stripped naphthalocyanines for multimodal tumor theranostics with upconversion guidance cream

Nanoscale. 2017 Mar 9;9(10):3391-3398. doi: 10.1039/c6nr09321c.

Authors

Yumiao Zhang¹, Hao Hong², Boyang Sun¹, Kevin Carter³, Yiru Qin³, Wei Wei⁴, Depeng Wang³, Mansik Jeon⁵, Jumin Geng³, Robert J Nickles⁶, Guanying Chen⁷, Paras N Prasad⁴, Chulhong Kim⁸, Jun Xia³, Weibo Cai⁶, Jonathan F Lovell¹

Affiliations

¹ Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu and Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
² Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan 48109, USA.
³ Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, New York 14260, USA. jflovell@buffalo.edu.
⁴ Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
⁵ School of Electronics Engineering, College of IT Engineering, Kyungpook National University, 702701, Korea.
⁶ Department of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA.
⁷ Institute for Lasers, Photonics, and Biophotonics and Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260, USA and School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, Heilongjiang 150001, People's Republic of China.
⁸ Creative IT Engineering, Pohang University of Science and Technology, 790784, Korea.

Abstract

Surfactant-stripped, nanoformulated naphthalocyanines (nanonaps) can be formed with Pluronic F127 and low temperature membrane processing, resulting in dispersed frozen micelles with extreme contrast in the near infrared region. Here, we demonstrate that nanonaps can be used for multifunctional cancer theranostics. This includes lymphatic mapping and whole tumor photoacoustic imaging following intradermal or intravenous injection in rodents. Without further modification, pre-formed nanonaps were used for positron emission tomography and passively accumulated in subcutaneous murine tumors. Because the nanonaps used absorb light beyond the visible range, a topical upconversion skin cream was developed for anti-tumor photothermal therapy with laser placement that can be guided by the naked eye.

MeSH terms

Animals
Female
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Nanoparticles
Neoplasms, Experimental / therapy*
Phototherapy*
Surface-Active Agents
Theranostic Nanomedicine*
Tissue Distribution

Substances

Surface-Active Agents

Abstract

MeSH terms

Substances

Grants and funding