Sterols from Thai Marine Sponge Petrosia (Strongylophora) sp. and Their Cytotoxicity

Mar Drugs. 2017 Feb 23;15(3):54. doi: 10.3390/md15030054.

Abstract

Eight new sterols (1-5 and 11-13), together with eight known compounds (6-10 and 14-16) were isolated from marine sponge Petrosia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The cytotoxicity of some compounds against a panel of human cancer cell lines is also reported.

Keywords: Petrosia sp.; cytotoxicity; sterol.

MeSH terms

  • A549 Cells
  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • HeLa Cells
  • Hep G2 Cells
  • Humans
  • Neoplasms / drug therapy*
  • Petrosia / chemistry*
  • Porifera / chemistry*
  • Sterols / chemistry*
  • Sterols / pharmacology*
  • Thailand

Substances

  • Antineoplastic Agents
  • Sterols