[Immunotherapy for the treatment of patients with genitourinary cancers: Review and perspectives]

Bull Cancer. 2017 Apr;104(4):370-379. doi: 10.1016/j.bulcan.2017.01.009. Epub 2017 Feb 23.
[Article in French]

Abstract

Management of genitourinary (GU) cancers is improving rapidly with the development of immunotherapy agents, especially anti-PD-1/anti-PD-L1 therapies. Large studies have shown better outcomes for the treatment of these patients, leading to new drug approvals and recent changes in standards of care in renal, prostate and bladder cancer. We performed a review of recent studies assessing efficacy of immuno-oncology therapies in GU cancers. New results are summarized and next ways of development of clinical research are discussed as the use of such therapies will soon be assessed in first-line or adjuvant settings.

Keywords: Cancers génito-urinaires; Genitourinary cancer; Immunotherapy; Immunothérapie; Review; Revue.

Publication types

  • Review

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Humanized / therapeutic use
  • Cancer Vaccines / administration & dosage
  • Carcinoma, Renal Cell / pathology
  • Carcinoma, Renal Cell / therapy
  • Humans
  • Immunotherapy / methods*
  • Immunotherapy, Adoptive / methods
  • Kidney Neoplasms / pathology
  • Kidney Neoplasms / therapy*
  • Male
  • Nivolumab
  • Programmed Cell Death 1 Receptor / antagonists & inhibitors
  • Prostatic Neoplasms / therapy*
  • Urinary Bladder Neoplasms / therapy*
  • Urogenital Neoplasms / therapy*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Cancer Vaccines
  • Programmed Cell Death 1 Receptor
  • durvalumab
  • Nivolumab
  • atezolizumab
  • pembrolizumab
  • avelumab