Metabolic brain adaptations to recurrent hypoglycaemia may explain the link between type 1 diabetes mellitus and epilepsy and point towards future study and treatment options

Diabetologia. 2017 May;60(5):938-939. doi: 10.1007/s00125-017-4231-5. Epub 2017 Feb 24.
No abstract available

Keywords: Brain metabolism; Epilepsy; Hypoglycaemia; Lactate; Type 1 diabetes; β-hydroxybutyrate.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood-Brain Barrier
  • Case-Control Studies
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / physiopathology*
  • Epilepsy / complications*
  • Epilepsy / physiopathology*
  • Female
  • Humans
  • Hypoglycemia / complications
  • Hypoglycemia / physiopathology
  • Ketones
  • Male
  • Models, Neurological
  • Neurons / physiology
  • Recurrence
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Ketones