Synthesis of Ring-Fused 1-Benzazepines via [1,5]-Hydride Shift/7-Endo Cyclization Sequences

Org Lett. 2017 Mar 17;19(6):1334-1337. doi: 10.1021/acs.orglett.7b00184. Epub 2017 Feb 24.

Abstract

Synthesis of 1-benzazepines has been achieved via a [1,5]-hydride shift/7-endo cyclization sequence. The focus of this research is a direct transformation of 2-(aryl)cyclopropane 1,1-diester derivatives into 1-benzazepines using a cyclopropane moiety as the hydride acceptor in internal redox reactions.

Publication types

  • Research Support, Non-U.S. Gov't