The effect of lipophilic amines on the growth of hepatitis A virus in Frp/3 cells

F Superti; L Seganti; N Orsi; M Divizia; R Gabrieli; A Panà

doi:10.1007/BF01320970

The effect of lipophilic amines on the growth of hepatitis A virus in Frp/3 cells

Arch Virol. 1987;96(3-4):289-96. doi: 10.1007/BF01320970.

Authors

F Superti¹, L Seganti, N Orsi, M Divizia, R Gabrieli, A Panà

Affiliation

¹ Istituto di Microbiologia, Università di Roma La Sapienza, Facoltà di Medicina e Chirurgia, Italy.

PMID: 2821967
DOI: 10.1007/BF01320970

Abstract

The effect of lipophilic amines on hepatitis A virus infection in a monkey cell line (Frp/3 cells) was studied. Ammonium chloride, amantadine, methylamine and dansylcadaverine inhibited viral antigen synthesis when added to the cells at least one hour after the attachment step. Results obtained suggest that the HAV entry pathway in Frp/3 cells follows an endocytic route and that viral uncoating takes probably place in endosomes and/or lysosomes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amantadine / pharmacology*
Ammonium Chloride / pharmacology*
Animals
Cadaverine / analogs & derivatives*
Cadaverine / pharmacology
Cell Line
Cytopathogenic Effect, Viral
Diamines*
Endocytosis / drug effects
Haplorhini
Hepatovirus / drug effects
Hepatovirus / physiology*
Lysosomes / drug effects
Methylamines / pharmacology*

Substances

Diamines
Methylamines
Ammonium Chloride
Amantadine
methylamine
monodansylcadaverine
Cadaverine