Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

Ping-Chung Kuo; Hsin-Yi Hung; Chi-Wei Nian; Tsong-Long Hwang; Ju-Chien Cheng; Daih-Huang Kuo; E-Jian Lee; Shih-Huang Tai; Tian-Shung Wu

doi:10.1021/acs.jnatprod.6b01141

Chemical Constituents and Anti-inflammatory Principles from the Fruits of Forsythia suspensa

J Nat Prod. 2017 Apr 28;80(4):1055-1064. doi: 10.1021/acs.jnatprod.6b01141. Epub 2017 Feb 20.

Authors

Ping-Chung Kuo¹, Hsin-Yi Hung¹, Chi-Wei Nian², Tsong-Long Hwang³, Ju-Chien Cheng⁴, Daih-Huang Kuo⁵, E-Jian Lee⁶, Shih-Huang Tai⁶, Tian-Shung Wu^{1

5}

Affiliations

¹ School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan 701, Taiwan.
² Department of Chemistry, National Cheng Kung University , Tainan 701, Taiwan.
³ Graduate Institute of Natural Products, College of Medicine, Chang Gung University; Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology; and Department of Anesthesiology, Chang Gung Memorial Hospital , Taoyuan 333, Taiwan.
⁴ Department of Medical Laboratory Science and Biotechnology, China Medical University , Taichung 404, Taiwan.
⁵ Department of Pharmacy, College of Pharmacy and Health Care, Tajen University , Pingtung 907, Taiwan.
⁶ Department of Surgery and Anesthesiology and Institute of Biomedical Engineering, National Cheng Kung University, Medical Center and Medical School , Tainan 701, Taiwan.

PMID: 28218000
DOI: 10.1021/acs.jnatprod.6b01141

Abstract

Fifty compounds were isolated from the fruits of Forsythia suspensa, including 13 new compounds characterized as eight new diterpenoids (1-8), three new lignans (9-11), a new iridoid (12), and a new triterpenoid (13). Their structures were established on the basis of spectroscopic and spectrometric analysis. Most of the isolated compounds were examined for their anti-inflammatory activity in vitro. The results showed that several compounds displayed significant inhibition of fMLP/CB-induced superoxide anion generation and elastase release, with IC₅₀ values ranging from 0.6 ± 0.1 to 8.6 ± 0.8 μg/mL and from 0.8 ± 0.3 to 7.3 ± 1.1 μg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / chemistry
Anti-Inflammatory Agents / isolation & purification*
Anti-Inflammatory Agents / pharmacology*
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology*
Forsythia / chemistry*
Fruit / chemistry*
Humans
Lignans / chemistry
Lignans / isolation & purification*
Lignans / pharmacology*
Molecular Structure
Neutrophils / drug effects
Pancreatic Elastase / drug effects
Pancreatic Elastase / metabolism
Superoxides / metabolism
Taiwan

Substances

Anti-Inflammatory Agents
Diterpenes
Lignans
Superoxides
Pancreatic Elastase