Withanolides from aerial parts of Nicandra physalodes

Mu-Yuan Yu; Gao-Ting Zhao; Jie-Qing Liu; Afsar Khan; Xing-Rong Peng; Lin Zhou; Jin-Run Dong; Hai-Zhou Li; Ming-Hua Qiu

doi:10.1016/j.phytochem.2017.02.009

Withanolides from aerial parts of Nicandra physalodes

Phytochemistry. 2017 May:137:148-155. doi: 10.1016/j.phytochem.2017.02.009. Epub 2017 Feb 16.

Authors

Mu-Yuan Yu¹, Gao-Ting Zhao², Jie-Qing Liu³, Afsar Khan⁴, Xing-Rong Peng⁵, Lin Zhou⁵, Jin-Run Dong⁶, Hai-Zhou Li⁷, Ming-Hua Qiu⁸

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Graduate University of the Chinese Academy of Sciences, Beijing 100049, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
² Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
³ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
⁴ Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan.
⁵ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
⁶ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China.
⁷ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. Electronic address: lihaizhou@yninfo.com.
⁸ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China; Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China. Electronic address: mhchiu@mail.kib.ac.cn.

PMID: 28215420
DOI: 10.1016/j.phytochem.2017.02.009

Abstract

Twenty withanolides, including previously unknown nicanlodes A-M, were isolated from aerial parts of Nicandra physalodes. Their structural elucidations were unambiguously achieved through interpretation of extensive spectroscopic data (NMR and HRMS) and by comparison with literature data. Nicanlodes A and B have an unusual aromatic amine moiety. The isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines.

Keywords: Cytotoxicity; Nicandra physalodes; Solanaceae; Withanolides.

MeSH terms

Cell Line, Tumor
Humans
Molecular Structure
Plant Components, Aerial / chemistry
Plant Extracts / chemistry
Solanaceae / chemistry*
Withanolides / chemistry*
Withanolides / isolation & purification

Substances

Plant Extracts
Withanolides