Extracellular regulation of BMP signaling: welcome to the matrix

Biochem Soc Trans. 2017 Feb 8;45(1):173-181. doi: 10.1042/BST20160263.

Abstract

Given its importance in development and homeostasis, bone morphogenetic protein (BMP) signaling is tightly regulated at the extra- and intracellular level. The extracellular matrix (ECM) was initially thought to act as a passive mechanical barrier that sequesters BMPs. However, a new understanding about how the ECM plays an instructive role in regulating BMP signaling is emerging. In this mini-review, we discuss various ways in which the biochemical and physical properties of the ECM regulate BMP signaling.

Keywords: ECM; bone morphogenetic protein; collagen; hyaluronic acid; mechanosignaling; proteoglycan.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Morphogenetic Protein Receptors / metabolism
  • Bone Morphogenetic Proteins / metabolism*
  • Extracellular Matrix / metabolism*
  • Extracellular Matrix Proteins / metabolism
  • Extracellular Space / metabolism*
  • Homeostasis
  • Humans
  • Models, Biological
  • Signal Transduction*

Substances

  • Bone Morphogenetic Proteins
  • Extracellular Matrix Proteins
  • Bone Morphogenetic Protein Receptors