Probing Skin for Metabolites and Topical Drugs with Hydrogel Micropatches

Ewelina P Dutkiewicz; Hsien-Yi Chiu; Pawel L Urban

doi:10.1021/acs.analchem.6b04276

Probing Skin for Metabolites and Topical Drugs with Hydrogel Micropatches

Anal Chem. 2017 Mar 7;89(5):2664-2670. doi: 10.1021/acs.analchem.6b04276. Epub 2017 Feb 16.

Authors

Ewelina P Dutkiewicz¹, Hsien-Yi Chiu², Pawel L Urban^{1

3}

Affiliations

¹ Department of Applied Chemistry, National Chiao Tung University , 1001 University Road, Hsinchu, 300, Taiwan.
² Department of Dermatology, National Taiwan University Hospital Hsin-Chu Branch , 25 Jingguo Road, Hsinchu, 300, Taiwan.
³ Institute of Molecular Science, National Chiao Tung University , 1001 University Road, Hsinchu, 300, Taiwan.

PMID: 28192981
DOI: 10.1021/acs.analchem.6b04276

Abstract

Sampling the skin surface is a convenient way to obtain biological specimens bearing clinically relevant information. Hydrogel micropatches enable noninvasive collection of skin excretion specimens, which can subsequently be subjected to rapid mass spectrometric analysis providing insights into the skin metabolome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Administration, Topical
Animals
Humans
Hydrogels / chemistry*
Mass Spectrometry*
Metabolome*
Pharmaceutical Preparations / analysis*
Pharmaceutical Preparations / metabolism
Skin / metabolism*

Substances

Hydrogels
Pharmaceutical Preparations