RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways

Yiliu Liu; Rongtuan Lin; David Olagnier

doi:10.14800/ics.1491

RIGulation of STING expression: at the crossroads of viral RNA and DNA sensing pathways

Inflamm Cell Signal. 2017 Jan 1;4(1):e1491. doi: 10.14800/ics.1491.

Authors

Yiliu Liu¹, Rongtuan Lin², David Olagnier³

Affiliations

¹ Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, H3T 1E2 CANADA; Department of Medicine, McGill University, Montreal, H3T 1E2 CANADA.
² Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, H3T 1E2 CANADA; Department of Medicine, McGill University, Montreal, H3T 1E2 CANADA; Department of Microbiology & Immunology, McGill University, Montreal, H3T 1E2 CANADA.
³ Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, H3T 1E2 CANADA; Department of Medicine, McGill University, Montreal, H3T 1E2 CANADA; Department of Biomedicine, Aarhus Research Center for Innate Immunology, Aarhus University, Aarhus, 8000 Aarhus C DENMARK.

Abstract

The innate immune sensing of pathogens is important for host to mount defensive responses. STING has emerged in recent years as a critical signaling adaptor in the immune response to cytosolic DNA and RNA derived from pathogens. Liu et al. (2016) demonstrate that the RIG-I-dependent RNA sensing signaling induces STING expression via a TNF-α and IFN-α synergy. The up-regulation of STING is vital for 5'pppRNA restriction of HSV, a DNA virus that infects humans and causes herpes, in vitro and in vivo. This study provides new insights into the cross talk between DNA and RNA pathogen-sensing systems via the control of STING.

Keywords: 5′pppRNA; HSV; MAVS; RIG-I; RIG-I agonist; STING; antiviral response; cGAS; innate immunity; type I IFN.

Grants and funding

130401-1/Canadian Institutes of Health Research/Canada