Long-term Treatment With Sequential Molecular Targeted Therapy for Xp11.2 Translocation Renal Cell Carcinoma: A Case Report and Review of the Literature

Clin Genitourin Cancer. 2017 Jun;15(3):e503-e506. doi: 10.1016/j.clgc.2016.12.026. Epub 2016 Dec 29.

Authors

Katsura Kakoki¹, Yasuyoshi Miyata², Yasushi Mochizuki¹, Takahisa Iwata¹, Masayuki Obatake³, Kuniko Abe⁴, Takeshi Nagayasu⁵, Hideki Sakai¹

Affiliations

¹ Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
² Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. Electronic address: int.doc.miya@nagasaki-u.ac.jp.
³ Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan; Department of Surgery, Kochi Medical School, Kochi, Japan.
⁴ Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan.
⁵ Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

PMID: 28190703
DOI: 10.1016/j.clgc.2016.12.026

No abstract available

Keywords: Mammalian target of rapamycin inhibitor; Prognosis; Renal cell carcinoma; Sequential therapy; Tyrosine kinase inhibitor.

Publication types

Case Reports
Review

MeSH terms

Adult
Age of Onset
Antineoplastic Agents / therapeutic use
Axitinib
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / genetics
Carcinoma, Renal Cell / drug therapy*
Carcinoma, Renal Cell / genetics
Catheter Ablation
Child
Combined Modality Therapy / methods
Everolimus / therapeutic use
Fatal Outcome
Humans
Imidazoles / therapeutic use
Indazoles / therapeutic use
Indoles / therapeutic use
Kidney Neoplasms / drug therapy*
Kidney Neoplasms / genetics
Male
Molecular Targeted Therapy / methods*
Niacinamide / analogs & derivatives
Niacinamide / therapeutic use
Oncogene Fusion
Phenylurea Compounds / therapeutic use
Pyrroles / therapeutic use
Sorafenib
Sunitinib
Translocation, Genetic
Young Adult

Substances

Antineoplastic Agents
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Imidazoles
Indazoles
Indoles
Phenylurea Compounds
Pyrroles
TFE3 protein, human
Niacinamide
Everolimus
Sorafenib
Axitinib
Sunitinib