Dermatologic Reactions to Targeted Therapy: A Focus on Epidermal Growth Factor Receptor Inhibitors and Nursing Care

Nurs Clin North Am. 2017 Mar;52(1):83-113. doi: 10.1016/j.cnur.2016.11.005.

Abstract

Cancer treatments usually have side effects of bone marrow depression, mucositis, hair loss, and gastrointestinal issues. Rarely do we think of skin side effects until patients have been treated successfully with epidermal growth factor receptor inhibitors (EGFRi). Those reactions include papulopustular rash, hair changes, radiation dermatitis enhancement, pruritus, mucositis, xerosis, fissures, and paronychia. This article discusses the common skin reactions seen when using EGFRi and presents an overview of skin as the largest and important organ of the body, including an overview of skin assessment, pathophysiology of the skin reactions, nursing care involved, and introduction to oncodermatology.

Keywords: EGFRi (epidermal growth factor receptor inhibitors); Oncodermatology; Skin reactions.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use*
  • Drug-Related Side Effects and Adverse Reactions / etiology*
  • Drug-Related Side Effects and Adverse Reactions / nursing
  • Drug-Related Side Effects and Adverse Reactions / physiopathology
  • ErbB Receptors / adverse effects*
  • ErbB Receptors / therapeutic use*
  • Humans
  • Neoplasms / drug therapy*
  • Skin Diseases / etiology*
  • Skin Diseases / nursing
  • Skin Diseases / physiopathology

Substances

  • Antineoplastic Agents
  • ErbB Receptors