Marshall R. Urist and the discovery of bone morphogenetic proteins

Int Orthop. 2017 May;41(5):1065-1069. doi: 10.1007/s00264-017-3402-9. Epub 2017 Feb 11.

Abstract

Over the last 40 years International Orthopaedics has published a series of articles on bone morphogenetic proteins (BMPs) covering topics from basic research to clinical applications. This includes also work submitted from the Laboratory for Mineralized Tissues of the School of Medicine University of Zagreb. Accordingly, we felt obliged to give a short summary of Dr. Urist's life and work as our gratitude to his discovery that demineralized bone matrix (DBM) activity induces bone when implanted ectopically into the muscle or under the skin due to bone inducing proteins, named BMPs.

Keywords: Bone morphogenetic proteins; Bone regeneration; Heterotopic ossification; Marshall Urist.

Publication types

  • Biography
  • Historical Article

MeSH terms

  • Aged, 80 and over
  • Bone Morphogenetic Proteins*
  • Bone and Bones*
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Male
  • Medicine

Substances

  • Bone Morphogenetic Proteins

Personal name as subject

  • Marshall R Urist