Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection

Alexander M Aravanis; Mark Lee; Richard D Klausner

doi:10.1016/j.cell.2017.01.030

Next-Generation Sequencing of Circulating Tumor DNA for Early Cancer Detection

Cell. 2017 Feb 9;168(4):571-574. doi: 10.1016/j.cell.2017.01.030.

Authors

Alexander M Aravanis¹, Mark Lee¹, Richard D Klausner²

Affiliations

¹ GRAIL, Menlo Park, CA 94402, USA.
² GRAIL, Menlo Park, CA 94402, USA. Electronic address: klausner.rick@gmail.com.

PMID: 28187279
DOI: 10.1016/j.cell.2017.01.030

Abstract

Curative therapies are most successful when cancer is diagnosed and treated at an early stage. We advocate that technological advances in next-generation sequencing of circulating, tumor-derived nucleic acids hold promise for addressing the challenge of developing safe and effective cancer screening tests.

MeSH terms

DNA / blood*
Early Detection of Cancer
High-Throughput Nucleotide Sequencing / methods*
Humans
Neoplasms / diagnosis*
Neoplasms / genetics*
Sequence Analysis, DNA / methods*

Substances

DNA