Excessive consumption of fructose causes cardiometabolic dysfunctions through oxidative stress and inflammation

Can J Physiol Pharmacol. 2017 Oct;95(10):1078-1090. doi: 10.1139/cjpp-2016-0663. Epub 2017 Feb 10.

Abstract

A rapid rise in obesity, as well as physical inactivity, in industrialized countries is associated with fructose-consumption-mediated metabolic syndrome having a strong association with cardiovascular disease. Although insulin resistance is thought to be at the core, visceral obesity, hypertension, and hypertriglyceridemia are also considered important components of this metabolic disorder. In addition, various other abnormalities such as inflammation, oxidative stress, and elevated levels of uric acid are also part of this syndrome. Lifestyle changes through improved physical activity, as well as nutrition, are important approaches to minimize metabolic syndrome and its deleterious effects.

Keywords: activité physique; hypertension; inflammation; metabolic syndrome; oxidative stress; physical activity; stress oxydatif; syndrome métabolique.

Publication types

  • Review

MeSH terms

  • Animals
  • Blood Pressure
  • Dietary Sugars / adverse effects*
  • Fructose / adverse effects*
  • Healthy Lifestyle
  • Humans
  • Hypertension / blood
  • Hypertension / etiology
  • Hypertension / physiopathology
  • Hyperuricemia / blood
  • Hyperuricemia / etiology
  • Hyperuricemia / metabolism
  • Inflammation / blood
  • Inflammation / etiology*
  • Inflammation / physiopathology
  • Inflammation / therapy
  • Inflammation Mediators / blood
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / etiology*
  • Metabolic Syndrome / physiopathology
  • Metabolic Syndrome / therapy
  • Oxidative Stress*
  • Prognosis
  • Risk Factors
  • Risk Reduction Behavior
  • Uric Acid / blood

Substances

  • Dietary Sugars
  • Inflammation Mediators
  • Uric Acid
  • Fructose