Biomarkers of Heart Failure with Preserved and Reduced Ejection Fraction

Handb Exp Pharmacol. 2017:243:79-108. doi: 10.1007/164_2016_86.

Abstract

Biomarkers are increaingly being used in the management of heart failure not only for the purpose of screening, diagnosis, and risk stratification, but also as a guide to evaluate the response to treatment in the individual patient and as an entry criterion and/or a surrogate marker of efficacy in clinical trials testing novel drugs. In this chapter, we review the role of established biomarkers for heart failure management, according to the main classification of HF phenotypes, based on the measurement of left ventricular ejection fraction, including heart failure with reduced (<40%), preserved (≥50%), and, as recently proposed, mid-range (40-49%) ejection fraction.

Keywords: Biomarkers; Diagnosis; Heart failure management; Prognosis; Screening.

Publication types

  • Review

MeSH terms

  • Adrenomedullin / metabolism
  • Aldosterone / metabolism
  • Angiotensin II / metabolism
  • Atrial Natriuretic Factor / metabolism
  • Biomarkers / metabolism*
  • C-Reactive Protein / metabolism
  • Cardio-Renal Syndrome / metabolism
  • Catecholamines / metabolism
  • Chromogranin A / metabolism
  • Creatinine / metabolism
  • Galectin 3 / metabolism
  • Glycopeptides / metabolism
  • Growth Differentiation Factor 15 / metabolism
  • Heart Failure / metabolism*
  • Heart Failure / physiopathology
  • Hepatitis A Virus Cellular Receptor 1 / metabolism
  • Humans
  • Interleukin-1 / metabolism
  • Interleukin-1 Receptor-Like 1 Protein / metabolism
  • Interleukin-18 / metabolism
  • Interleukin-6 / metabolism
  • Lipocalin-2 / metabolism
  • MicroRNAs / metabolism
  • Natriuretic Peptide, Brain / metabolism
  • Peptide Fragments / metabolism
  • Renin / metabolism
  • Renin-Angiotensin System
  • Stroke Volume*
  • Troponin / metabolism
  • Troponin T / metabolism
  • Tumor Necrosis Factor-alpha / metabolism
  • beta-N-Acetyl-Galactosaminidase / metabolism

Substances

  • Biomarkers
  • Catecholamines
  • Chromogranin A
  • Galectin 3
  • Glycopeptides
  • Growth Differentiation Factor 15
  • HAVCR1 protein, human
  • Hepatitis A Virus Cellular Receptor 1
  • IL1RL1 protein, human
  • Interleukin-1
  • Interleukin-1 Receptor-Like 1 Protein
  • Interleukin-18
  • Interleukin-6
  • Lipocalin-2
  • MicroRNAs
  • Peptide Fragments
  • Troponin
  • Troponin T
  • Tumor Necrosis Factor-alpha
  • copeptins
  • midregional pro-atrial natriuretic peptide, human
  • pro-brain natriuretic peptide (1-76)
  • Angiotensin II
  • Natriuretic Peptide, Brain
  • Adrenomedullin
  • Aldosterone
  • Atrial Natriuretic Factor
  • C-Reactive Protein
  • Creatinine
  • beta-N-Acetyl-Galactosaminidase
  • Renin