Abstract
Evolution often diversifies a peptide hormone family into multiple subfamilies, which exert distinct activities by exclusive interaction with specific receptors. Here we show that systematic swapping of pre-existing variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional peptide that exerts activities beyond the original subfamily by interacting with multiple receptors. This approach provides new insights into the complexity and specificity of peptide signalling.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Arabidopsis / cytology
-
Arabidopsis / physiology*
-
Arabidopsis Proteins / chemical synthesis
-
Arabidopsis Proteins / physiology*
-
Biodiversity
-
Evolution, Molecular
-
Ligands
-
Molecular Docking Simulation
-
Molecular Structure
-
Peptide Hormones / chemical synthesis
-
Peptide Hormones / physiology*
-
Plant Growth Regulators / chemical synthesis
-
Plant Growth Regulators / physiology*
-
Plants, Genetically Modified
-
Stem Cells / metabolism
-
Stem Cells / physiology*
-
Structure-Activity Relationship
-
Substrate Specificity / physiology
Substances
-
Arabidopsis Proteins
-
Ligands
-
Peptide Hormones
-
Plant Growth Regulators