Abstract
Rats bearing Pliss' lymphosarcoma revealed diurnal variations of body temperature. Cyclophosphamide and methotrexate were significantly less toxic when injected at peak temperatures than at minimal ones.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Body Temperature / drug effects
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Body Weight / drug effects
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Circadian Rhythm / drug effects*
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Cyclophosphamide / administration & dosage*
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Cyclophosphamide / adverse effects
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Cyclophosphamide / toxicity
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Lymphoma, Non-Hodgkin / drug therapy
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Methotrexate / administration & dosage*
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Methotrexate / adverse effects
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Methotrexate / toxicity
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Neoplasm Transplantation
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Rats
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Time Factors
Substances
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Cyclophosphamide
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Methotrexate