[The prevention of the side effects of cytostatics by administering them at various times of day]

Vopr Onkol. 1989;35(9):1068-71.
[Article in Russian]

Abstract

Rats bearing Pliss' lymphosarcoma revealed diurnal variations of body temperature. Cyclophosphamide and methotrexate were significantly less toxic when injected at peak temperatures than at minimal ones.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Body Temperature / drug effects
  • Body Weight / drug effects
  • Circadian Rhythm / drug effects*
  • Cyclophosphamide / administration & dosage*
  • Cyclophosphamide / adverse effects
  • Cyclophosphamide / toxicity
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Lymphoma, Non-Hodgkin / drug therapy
  • Methotrexate / administration & dosage*
  • Methotrexate / adverse effects
  • Methotrexate / toxicity
  • Neoplasm Transplantation
  • Rats
  • Time Factors

Substances

  • Cyclophosphamide
  • Methotrexate