Abstract
A new benzylisoquinoline alkaloid (•)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).
Keywords:
Lauraceae; Litsea cubeba; X-ray diffraction; benzylisoquinoline; cytotoxicity.
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzylisoquinolines / chemistry
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Benzylisoquinolines / isolation & purification*
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Benzylisoquinolines / pharmacology
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Cisplatin / pharmacology
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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HL-60 Cells
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Humans
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Inhibitory Concentration 50
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Litsea / chemistry*
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Benzylisoquinolines
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N-methoxycarbonyl-norjuziphine
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norjuziphine
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Cisplatin