A new N-methoxyl-carbonyl benzylisoquinoline from Litsea cubeba

J Asian Nat Prod Res. 2017 Sep;19(9):941-945. doi: 10.1080/10286020.2016.1275582. Epub 2017 Feb 2.

Abstract

A new benzylisoquinoline alkaloid (•)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).

Keywords: Lauraceae; Litsea cubeba; X-ray diffraction; benzylisoquinoline; cytotoxicity.

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Benzylisoquinolines / chemistry
  • Benzylisoquinolines / isolation & purification*
  • Benzylisoquinolines / pharmacology
  • Cisplatin / pharmacology
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • HL-60 Cells
  • Humans
  • Inhibitory Concentration 50
  • Litsea / chemistry*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Roots / chemistry

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Benzylisoquinolines
  • N-methoxycarbonyl-norjuziphine
  • norjuziphine
  • Cisplatin