Tissue sodium accumulation and peripheral insulin sensitivity in maintenance hemodialysis patients

Abstract

Background: Recent data suggest that sodium (Na⁺ ) is stored in the muscle and skin without commensurate water retention in maintenance hemodialysis (MHD) patients. In this study, we hypothesized that excessive Na⁺ accumulation would be associated with abnormalities in peripheral insulin action.

Methods: Eleven MHD patients and eight controls underwent hyperinsulinemic-euglycemic-euaminoacidemic clamp studies to measure glucose (GDR) and leucine disposal rates (LDR), as well as lower left leg ²³ Na magnetic resonance imaging to measure Na⁺ concentration in the muscle and skin tissue.

Results: The median GDR and LDR levels were lower, and the median muscle Na⁺ concentration was higher in MHD patients compared with controls. No significant difference was found regarding skin Na⁺ concentration between group comparisons. Linear regression revealed inverse relationships between muscle Na⁺ concentration and GDR and LDR in MHD patients, whereas no relationship was observed in controls. There was no association between skin Na⁺ content and GDR or LDR in either MHD patients or controls.

Conclusions: These data suggest that excessive muscle Na⁺ content might be a determinant of IR in MHD patients, although the causality and mechanisms remain to be proven.

Keywords: Glucose disposal rate; Insulin resistance; Leucine disposal rate; Muscle sodium content.