A method for the production of complex cell-laden structures is reported, which allows high-levels of spatial control over mechanical and chemical properties. The potential of this method for producing complicated tissues is demonstrated by manufacturing a complex hard/soft tissue interface and demonstrating that cell phenotype can be maintained over four weeks of culture.
Keywords: additive layer manufacturing; cartilage; hydrogels; osteochondral; tissue engineering.
© 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.