Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

In Young Choi; Changhan Lee; Valter D Longo

doi:10.1016/j.mce.2017.01.042

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence

Mol Cell Endocrinol. 2017 Nov 5:455:4-12. doi: 10.1016/j.mce.2017.01.042. Epub 2017 Jan 28.

Authors

In Young Choi¹, Changhan Lee², Valter D Longo³

Affiliations

¹ Longevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Department of Microbiology, Immunology, Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
² Longevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA.
³ Longevity Institute, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Department of Neuroscience, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, CA 90089, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA; IFOM, FIRC Institute of Molecular Oncology, 20139, Milan, Italy. Electronic address: vlongo@usc.edu.

Abstract

Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence.

Keywords: Aging; Autoimmune diseases; Fasting; Fasting mimicking diet; Immunosenescence; Metabolism.

Publication types

Review

MeSH terms

Aging / immunology*
Animals
Arthritis, Rheumatoid / diet therapy*
Arthritis, Rheumatoid / immunology
Arthritis, Rheumatoid / pathology
Arthritis, Rheumatoid / prevention & control
Autoimmune Diseases
Caloric Restriction
Diabetes Mellitus, Type 1 / diet therapy*
Diabetes Mellitus, Type 1 / immunology
Diabetes Mellitus, Type 1 / pathology
Diabetes Mellitus, Type 1 / prevention & control
Diet / methods*
Disease Models, Animal
Fasting / metabolism
Humans
Immunosenescence
Mice
Multiple Sclerosis / diet therapy*
Multiple Sclerosis / immunology
Multiple Sclerosis / pathology
Multiple Sclerosis / prevention & control
Nutritional Status / immunology
T-Lymphocytes / classification
T-Lymphocytes / cytology
T-Lymphocytes / immunology*

Grants and funding

R01 AG052558/AG/NIA NIH HHS/United States