Exploring 1,3,4-Oxadiazole Scaffold for Anti-inflammatory and Analgesic Activities: A Review of Literature From 2005-2016

Mini Rev Med Chem. 2018;18(3):216-233. doi: 10.2174/1389557517666170127121215.

Abstract

1,3,4-Oxadiazole derivatives are found to have a wide range of pharmacological activities and attracting the researchers to work on this nucleus. Literature survey indicates that many 1,3,4- oxadiazoles have been synthesized with the aim to get compounds of significant anti-inflammatory and analgesic activities with reduced adverse effects. The purpose of this review is to compile the reports on 1,3,4-oxadiazole derivatives possessing anti-inflammatory and analgesic activities. The review also includes the reports on 1,3,4-oxadiazole derivatives of existing NSAIDs in the last ten years.

Keywords: 1; 3; 4-Oxadiazole; Analgesic; COX; NSAIDs; anti-inflammatory; scaffold.

Publication types

  • Review

MeSH terms

  • Analgesics / chemical synthesis
  • Analgesics / chemistry
  • Analgesics / therapeutic use*
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Humans
  • Inflammation / drug therapy*
  • Molecular Structure
  • Oxadiazoles / chemistry
  • Oxadiazoles / pharmacology*

Substances

  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Oxadiazoles
  • 1,3,4-oxadiazole