Inhibition of CYP2D6 with low dose (5 mg) paroxetine in patients with high 10-hydroxynortriptyline serum levels - a review of routine practice

Br J Clin Pharmacol. 2017 May;83(5):1149-1151. doi: 10.1111/bcp.13201. Epub 2017 Jan 29.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adrenergic Uptake Inhibitors / therapeutic use
  • Adult
  • Aged
  • Cytochrome P-450 CYP2D6 Inhibitors / pharmacology*
  • Cytochrome P-450 CYP2D6 Inhibitors / therapeutic use
  • Depression / blood
  • Depression / drug therapy
  • Drug Interactions
  • Female
  • Humans
  • Middle Aged
  • Nortriptyline / analogs & derivatives*
  • Nortriptyline / blood
  • Nortriptyline / therapeutic use
  • Paroxetine / pharmacology*

Substances

  • Adrenergic Uptake Inhibitors
  • Cytochrome P-450 CYP2D6 Inhibitors
  • 10-hydroxynortriptyline
  • Paroxetine
  • Nortriptyline